Fig. 4

Biological effects of circROBO2 in hypoxic cardiomyocytes in vitro. a, c Cell viability analysis of mouse cardiomyocytes. Cardiomyocytes were exposed to normoxic or hypoxia combined with transfecting with si-NC, si-circROBO2 + miR-1184 mimics, si-circROBO2 + miR-1184 or si-circROBO2 + si-TRADD. b, d Cell dysfunction of mouse cardiomyocytes exposed to normoxic or hypoxia combined with transfecting with si-NC, si-circROBO2 + miR-1184 mimics, si-circROBO2 + miR-1184 or si-circROBO2 + si-TRADD. All above the experiments were repeated three times. * vs normoxia control group, # vs si-NC group, & vs si-circROBO2 group. ***P < 0.001, ^##P < 0.01 and ^&P < 0.05