Fig. 7

RANKL‑induced activation of NF‑κB and JNK signaling pathways was attenuated by ZOL treatment in human osteoclast precursor cells (*P value < 0.05 vs. NC group; #P value < 0.05 vs. RANKL group; ^P value < 0.05 vs. RANKL + ZOL + Scramble control group). a Western blot analysis showed ZOL treatment restored the normal expression of genes related to NF‑κB and JNK signaling pathways, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation. b Quantitative analysis of Western blot showed that RANKL induced-upregulation of p-lκBα/lκBα expression was suppressed by ZOL treatment, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation. c Quantitative analysis of Western blot showed that RANKL induced-upregulation of p-p65/p65 expression was suppressed by ZOL treatment, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation. d Quantitative analysis of Western blot showed that RANKL induced-upregulation of p-JNK/JNK expression was suppressed by ZOL treatment, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation. e Quantitative analysis of Western blot showed that RANKL induced-upregulation of p-p38/p38 expression was suppressed by ZOL treatment, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation. f Quantitative analysis of Western blot showed that RANKL induced-upregulation of p-ERK/ERK expression was suppressed by ZOL treatment, while the knockdown of miR-302, miR-101 and miR-145 reversed this situation