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Fig. 1 | Molecular Medicine

Fig. 1

From: Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition

Fig. 1

CC16 inhibits HDM-induced airway epithelial injury and inflammation in vivo. a Experimental protocol for the establishment of HDM-induced murine asthmatic model and treatment with recombinant CC16. b The counts of total and differential inflammatory cells in BALF from control group, HDM group, HDM + CC16-5 (treated with 5 ug/g CC16) group, and HDM + CC16-10 (treated with 10 ug/g CC16) group by Wright staining. c–f The levels of IL-4, IL-5, IL-13 and HDM-sIgE in BALF were measured using ELISA assay. g Representative lung sections from each group were analyzed with H&E or PAS staining. Scale bars = 100 μm. Data are expressed as means ± standard error of the mean (SEM). ##p < 0.01 vs. Control group;*p < 0.05 vs. HDM group; **p < 0.01 vs. HDM group

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Molecular Medicine

ISSN: 1528-3658