Mechanism | Intervention | ClinTrial Indentifier | Phase | Τarget population | Primary outcome | Other secondary outcomes of interest | Sponsor |
---|---|---|---|---|---|---|---|
Gene therapies | Vector genome: VY-AADC02 | NCT03562494 | II | Moderate to Advanced PD with motor Fluctuations | Changes in ON time without troublesome dyskinesia | . | Neurocrine Biosciences |
Lentiviral vector: OXB-102 | NCT03720418 | I/II | Bilateral PD | AE, SAE, Changes in MRI | . | Sio Gene Therapies | |
Neuromodulation | MRgFUS | NCT04002596 NCT03319485 NCT02263885 NCT02246374 NCT03608553 | NA | Advanced PD | AE, Responders, Changes in CRST, Changes in MDS-UPDRS | . | InSightec |
Neuromodulation | rTMS | NCT04238000 | NA | PD | Motor Outcomes | . | Fondazione Europea di Ricerca Biomedica Ferb Onlus |
NCT04431570 | NA | PD, freezing of gait | Changes in FOGT | fMRI | Peking Union Medical College Hospital | ||
NCT04116216 | II | PD | Changes in MDS-UPDRS part III | . | Universidade Federal de Pernambuco | ||
NCT03836950 | I/II | PD | Changes in Cognitive Outcomes | . | VA Office of Research and Development | ||
NCT02346708 | NA | PD with MCI | Changes in magnetoencephalography connectivity measures | . | University of Colorado, Denver | ||
NCT03552861 | NA | PD with Depression or Cognitive Impairment | Changes in HAMD and BDI | . | Guangdong Provincial People’s Hospital |