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Fig. 5 | Molecular Medicine

Fig. 5

From: Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway

Fig. 5

Inhibition of lipoxin A4 receptor (ALXR) abolishes the beneficial effects of MaR1 in I/R-induced liver damage. a Western blot of whole-cell lysates from primary mouse HC and NPC assessing protein expression of ALXR at the baseline. WT mice were treated with/without ALXR inhibitor (Boc2; 50 mg/kg, i.p.) 1 h prior to liver I/R with PBS or MaR1 (20 ng/mouse, i.v.) b, c Serum ALT and AST levels in indicated groups after 6 h reperfusion (n=3 in sham groups; n=6 in I/R groups). d Representative liver H&E staining (original magnification ×20) from indicated groups. e Quantitation of liver necrotic areas, quantified in bar graph; n = 5 for each I/R group; f Serum IL-6 levels in indicated groups. g Western blot analysis of cleaved-caspase 3 in liver tissue from mice subjected to I/R insult in the indicated group. Data are presented as mean ± SEM. *P\(<\) 0.05, **P\(<\) 0.01

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