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Fig. 7 | Molecular Medicine

Fig. 7

From: Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway

Fig. 7

Proposed hepatoprotective signaling mechanisms mediated by MaR1 in liver I/R injury. MaR1 confers protection against I/R-induced liver damage through interacting with ALXR, thus resulting in enhancing downstream p-Akt protein expression. MaR1 also exerts its protective role during hepatic I/R injury by increasing antioxidant enzyme activity (GPX), inhibiting the activation of ERK and suppressing inflammatory responses, and finally contributes to decreased apoptotic cell death

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