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Fig. 6 | Molecular Medicine

Fig. 6

From: TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells

Fig. 6

Roles of C/EBPβ deacetylation in TGF-β-induced EMT and collagen deposition. a A549 cells were treated with TGF-β (10 ng/mL) for 24 h. Western blotting showing TGF-β treatment led to acetylation of C/EBPβ and increased the levels of α-SMA proteins. b Deacetylation of C/EBPβ via SIRT1 administered in A549 cells rectified TGF-β-induced elevation in collagen-I deposition. c Quantification of western blots were calculated according to grey analysis. d SIRT1 suppressed the increased C/EBPβ-luciferase activity in TGF-β-treated A549 cells. Data show mean ± SEM. Asterisk (*) denotes significant difference (P < 0.05) compared to the control

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