Fig. 1

Complement activation during the first 24 hours after trauma. Individual Terminal Complement Complex (TCC) concentration curves for the 124 trauma patients with documented admission base excess (BE), grouped by severity of anatomical injury (New Injury Severity Score, NISS) and physiological derangement (BE). Black dashed lines represent median TCC concentration and grey corresponding areas interquartile ranges for the reference population of 20 healthy volunteers. The grey shaded columns show the time interval used for computation of area under the TCC concentration curve 3–6 hours after injury (TCC-AUC_3–6)