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Table 2 Pathological characteristics in two group of patients. Data are presented as proportion of individuals within each category

From: E2F1 copy number variations in germline and breast cancer: a retrospective study of 222 Italian women

 

CNV = 2

CNV > 2

P value

Age at diagnosis (years)

60.4 ± 14.5

61.4 ± 13.6

0.74

Menopausal status

0.70

 Premenopausal

20.9%

10%

 Perimenopausal

3.7%

0.0%

 Menopausal

75.4%

90%

Estrogen receptor

0.84

 Positive

67.8%

80%

 Negative

32.2%

20%

Progesterone receptor

0.35

 Positive

53%

30%

 Negative

47%

70%

HER-2 status

0.99

 Positive

70.1%

70%

 Negative

29.9%

30%

Palpable tumour

0.07

 Yes

93.6%

70%

 No

6.4%

30%

Lymph node status

0.04*

 Negative

58.2%

80%

 Positive

41.8%

20%

Tumour type

0.93

 Invasive ductal carcinoma (IDC)

72.9%

80%

 Ductal carcinoma in situ (DCIS)

5.7%

0.0%

 Lobular

15.7%

20%

 D & L

1%

0.0%

 Other

2.9%

0.0%

Histological grade

0.36

 I

11.1%

0%

 II

51.9%

70%

 III

37%

30%

Location

0.04*

 Unilateral

95.5%

80%

 Bilateral

2.5%

20%

Familial history

0.001*

 Yes

45%

100%

 No

55%

0%

Size (cm)

0.64

 < 2

59%

60%

 > 2

41%

40%

Vascular invasion

0.21

 Yes

81%

0%

 No

19%

100%

  1. * p value < 0.05