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Table 3 Description of phenotypic characteristics of 35 out of 222 patients on which E2F1 expression and copy number assay were performed

From: E2F1 copy number variations in germline and breast cancer: a retrospective study of 222 Italian women

  CNV = 2, (N = 31) CNV > 2, (N = 4) P value
Age at diagnosis (years) 60.48 ± 16.76 57.5 ± 10.88 0.808
Menopausal status 0.458
 Premenopausal 25.8% 0%
 Perimenopausal 3.2% 0%
 Menopausal 71.0% 100%
Estrogen receptor 0.523
 Positive 83.9% 100%
 Negative 16.1% 0%
Progesterone receptor 0.454
 Positive 86.2% 100%
 Negative 19.4% 0%
HER-2 status 0.082
 Positive 74.2% 25%
 Negative 25.8% 75%
Palpable tumour 0.601
 Yes 87.1% 100%
 No 12.9% 0%
Lymph node status 0.082
 Negative 25.8% 75%
 Positive 74.2% 25%
Tumour type 0.791
 Invasive ductal carcinoma (IDC) 80.6% 75%
 Ductal carcinoma in situ (DCIS) 0% 0%
 Lobular 19.4% 25%
 D & L 0% 0%
 Other 0% 0%
Histological grade 0.304
 I 9.7% 0%
 II 35.5% 75%
 III 54.8% 25%
Location 0.114
 Unilateral 100% 75%
 Bilateral 0% 25%
Familial history < 0.001
 Yes 6.5% 100%
 No 93.5% 0%
Size 0.530
 < 2 cm 38.7% 50%
 > 2 cm 61.3% 50%
Vascular invasion 0.553
 Yes 29% 0%
 No 71% 100%