TY - JOUR AU - Khan, Muhammad Babar AU - Ruggieri, Rosamaria AU - Jamil, Eesha AU - Tran, Nhan L. AU - Gonzalez, Camila AU - Mugridge, Nancy AU - Gao, Steven AU - MacDiarmid, Jennifer AU - Brahmbhatt, Himanshu AU - Sarkaria, Jann N. AU - Boockvar, John AU - Symons, Marc PY - 2021 DA - 2021/03/25 TI - Nanocell-mediated delivery of miR-34a counteracts temozolomide resistance in glioblastoma JO - Molecular Medicine SP - 28 VL - 27 IS - 1 AB - Glioblastoma is the most common primary brain tumor and remains uniformly fatal, highlighting the dire need for developing effective therapeutics. Significant intra- and inter-tumor heterogeneity and inadequate delivery of therapeutics across blood–brain barrier continue to be significant impediments towards developing therapies which can significantly enhance survival. We hypothesize that microRNAs have the potential to serve as effective therapeutics for glioblastoma as they modulate the activity of multiple signaling pathways, and hence can counteract heterogeneity if successfully delivered. SN - 1528-3658 UR - https://doi.org/10.1186/s10020-021-00293-4 DO - 10.1186/s10020-021-00293-4 ID - Khan2021 ER -