Identification of prognostic alternative splicing events related to the immune microenvironment of hepatocellular carcinoma

Table 1 Patient characteristics at baseline

Characteristic	Number (%)
Diagnosis age
< 60	201 (54.3)
≥ 60	169 (45.7)
Median age (range), years	53 (16–90)
Gender
male	250 (67.6)
female	120 (32.4)
Origin (race)
Asia	158 (42.7)
Non-Asia	212 (57.3)
Ethnicity
Hispanic or Latino	132 (35.7)
Not Hispanic or Latino	227 (61.4)
NA	11 (2.9)
ECOG performance status score^a
0	162 (43.8)
1	84 (22.7)
2	26 (7.0)
> 2	98 (26.5)
Child–Pugh classification grade^b
A	216 (58.4)
B	21 (5.7)
C	1 (0.2)
NA	132 (35.7)
Disease Stage (American Joint Committee on Cancer)
Stage I–II	256 (69.2)
Stage III	85 (23.0)
Stage IV	5 (1.3)
NA	24 (6.5)
AFP
≥ 400 ng per milliliter	64 (17.3)
< 400 ng per milliliter	213 (57.6)
NA	93 (25.1)
Family history of cancer
Yes	112 (30.3)
No	207 (55.9)
NA	51 (13.8)
Histologic grade^c
G1	55 (14.9)
G2	177 (47.8)
G3	121 (32.7)
G4	12 (3.3)
NA	5 (1.3)
Adjacent hepatic tissue inflammation extent type
None	117 (31.6)
Mild	99 (26.8)
Severe	17 (4.6)
NA	137 (37.0)

^aEastern Cooperative Oncology Group (ECOG) scores range from 0 to 5, with higher numbers indicating poorer health
^bThe Child–Pugh classification grade is a three-category scale (A, with scores of 5 or 6, indicating good hepatic function; B, with scores of 7 to 9, indicating moderately impaired hepatic function; or C, with scores of 10 to 15, indicating advanced hepatic dysfunction). Classification is determined by scoring according to the presence and severity of five clinical measures of liver disease (encephalopathy, ascites, bilirubin levels, albumin levels, and prolonged prothrombin time)
^cThe histologic grade of hepatocellular carcinoma is based on Edmondson's classification, which can be divided into four grades. The higher the grade, the worse the differentiation

ISSN: 1528-3658