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Table 2 Exosomal miRNAs in tuberculosis

From: The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection

Exosomal miRNA Source Conclusion Method for exosomes Refs
miR-484, miR-425, and miR-96 Serum The findings of this research indicate that exosomal miRNAs have a potential capacity for the diagnosis of active TB Total exosome isolation (TEI) reagent (Invitrogen, Thermo Fisher Scientific Corporation, USA) Mortaz et al. (2019)
miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486 Plasma This study's results have indicated that the combination of exosomal miRNAs and EHRs might enhance the medical diagnosis of TBM and PTB ExoQuick Kit (System Biosciences, USA) Hu et al. (2019)
hsa-let-7e-5p, hsa-let-7d-5p, hsa-miR-450a-5p, and hsa-miR-140-5p, hsa-miR-1246, hsa-miR-2110, hsa-miR-370-3P, hsa-miR-28-3p, and hsa-miR-193b-5p Serum This research's outcomes recommended that exosomal miRNA use could promote novel molecular targets to distinguish LTBI and active TB Differential centrifugation, filteration, and ultrafiltration Lyu et al. (2019)
hsa-miR-140-3p, hsa-miR-3184-5p and hsa-miR-423-3p Serum The study’s findings imply the preferential packing of RNA loads for exosomes at various steps of Mtb infection and promote further analysis and production of TB pathogenesis Differential centrifugation, filteration, and ultrafiltration Lyu et al. (2018)
miR-1224, -1293, -425, -4467, -4732, -484, -5094, -6848–6849, -4488 and -96 PBMCs This study's findings offer support for the release of unique exosomal miRNAs from BCG-infected MDMs, which highlighted the interaction between host and pathogen following infection Total exosome isolation (TEI) reagent (Invitrogen by the Thermo Fisher Scientific Corporation, Waltham, MA, USA) Alipoor et al. (2017)
Over 100 transcripts were found, such as 99b-5p, Mmu 30c, Mmu 30a, Mmu 191, Mmu 378, Mmu 210, Mmu 423-5p and Mmu 486-5p Cell culture, Mtb infected RAW264.7 macrophages This study has shown that there is discriminating packing of RNA material in exosomes after Mtb infection Centrifugetion, filtration and linear sucrose gradient Singh et al. (2015a)
miR-205-5p, miR-483-5p, miR-375, miR-200c-3p, miR-429, miR-200b-3p, miR-200a-3p, miR-203a-3p, and miR-141-3p Pleural effusion This study's outcomes have revealed that distinct miRNA profiles could be promising as biomarkers for differential determination of PEs with further confirmation dependent on larger cohorts Differential centrifugation, filteration, and ultrafiltration Wang et al. (2017)
  1. TB, Tuberculosis; HERs, electronic health records; PTB, pulmonary tuberculosis; TBM, tuberculous meningitis; LTBI, latent TB infection; TEM, Transmission electron microscopes; Mtb, Mycobacterium tuberculosis; PBMCs, Peripheral Blood Mononuclear Cells