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Table 3 Exosomal miRNA during active versus latent stage of tuberculosis and their implication in the different stages

From: The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection

Exosomal miRNA Source Changing trend Active tuberculosis Latent tuberculosis References
miR-484, miR-425, miR-96 Serum Up The expression of miR-484, miR-425, and miR-96 was significantly increased in serum of TB patients, which correlated with the TB infection level. These results demonstrate that exosomal miRNAs have diagnostic potential in active tuberculosis Alipoor et al. (2019a)
hsa-let-7e-5p, hsa-let-7d-5p, hsa-miR-450a-5p, and hsa-miR-140-5p Serum Up In a study, in LTBI, hsa-let-7e-5p, hsa-let-7d-5p, hsa-miR-450a-5p, and hsa-miR-140-5p were found. Some members of the hsa-let-7 family were reported to play roles in the immune response to Mtb infection Fu et al. (2011), Lyu et al. (2019)
hsa-miR-1246, hsa-miR-2110, hsa-miR-370-3P, hsa-miR-28-3p, and hsa-miR-193b-5p Serum Up In TB samples hsa-miR-1246, hsa-miR-2110, hsa-miR-370-3P, hsa-miR-28-3p, and hsa-miR-193b-5p 5p were found. These specifically expressed miRNAs and differentially expressed miRNAs in different panels and patterns provide potential biomarkers for the detection/diagnosis of latent and active TB using exosomal miRNAs Lyu et al. (2019)
miR‐148a‐3p, miR‐150‐5p, and miR‐451a Pleural effusion Up A study found that miR-148a-3p, miR-451a, and miR-150- could distinguish TB from benign lesions. Hence these miRNAs barely searched in TB, which prompted new biomarkers in the diagnosis of TB Wang et al. (2017)
miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486 Plasma Up In a study identified 6 exosomal miRNAs (miR-20a, miR-20b, miR-26a, miR-106a, miR-191, miR-486) in TB patients, 3 out of which (miR-20b, miR-191 and miR-486) showed a significant discriminatory value for pulmonary TB (PTB), TB meningitis (TBM) Hu et al. (2019)