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Fig. 7 | Molecular Medicine

Fig. 7

From: LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis

Fig. 7

Ectopic LRRC4 expression alleviates EAE progression. a Clinical scores of MOG-immunized WT mice after intravenously injected with adeno-associated virus (AAV) vector containing LRRC4 (AAV-LRRC4) or control virus vector (AAV-CON). Data represent the mean clinical scores of 8 mice per group ± SEM. b Body mass of EAE mice after intravenously injected with AAV-LRRC4 and AAV-CON. Data represent the mean body mass of 8 mice per group ± SEM. c Histopathological analysis of neuroinflammation and demyelination in spinal cords of mice 15 days after EAE induction. Sections were subjected to H&E staining, LFP staining and immumohistochemical staining with anti-IBA1 and anti-GFAP antibody. d Western blotting analysis of various proteins in brains and spinal cords in EAE mice after intravenously injected AAV-LRRC4 and AAV-CON. *p < 0.05

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