Fig. 8

The relationship between circPTK2, miR-181c-5p and HMGB1 in CLP-induced mice. a–d The expressions of circPTK2, miR-181c-5p and HMGB1 in the hippocampus tissues of mice in the Sham, CLP, CLP + siNC, CLP + sicirc, CLP + sicirc + antagomir groups were detected by qRT-PCR and Western blot. N = 3 for each column; ***P < 0.001 vs. Sham; ^{^^^}P < 0.001 vs. CLP + siNC; ^###P < 0.001 vs. CLP + siCirc; One-way ANOVA followed by Bonferroni's post-hoc test. e Kaplan–Meier curve was used to calculate the survival rate of mice in each group. N = 15. CLP Cecal Ligation and Puncture; Sicirc sicircPTK2; qRT-PCR quantitative reverse transcription real time polymerase chain reaction. β-actin or U6 were used as control