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Fig. 2 | Molecular Medicine

Fig. 2

From: CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis

Fig. 2

Differential expression of circular RNAs (circRNAs) in cartilage. A Screening flow of circRNAs. B Quantitative real-time polymerase chain reaction was used to assess interleukin (IL)-1β and IL-6 expression in three selected pairs of intact and damaged cartilage samples. C Western blotting was used to assess IL-1β and IL-6 expression in three selected pairs of intact and damaged cartilage samples. D Hierarchical clustering analysis of differentially expressed circRNAs between damaged and intact cartilage (> onefold difference in expression; p < 0.05). E The volcano map of circRNA expression (x-axis, log2 ratio of circRNA expression levels; y-axis, false discovery rate of circRNA [− log10 conversion]). F Frequency distribution of circRNA length (x-axis, range of circRNA length; y-axis: frequency of circRNAs of specific lengths)

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