Fig. 6
From: LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production
IL-2 was involved in the role of H19. A and B The level of active IL-2 (A) and total IL-2 (B) in cultured supernatants of BMMSCs from SLE patients and health controls was detected by ELISA assay. C–F BMMSCs were transfected with or without H19-NC, H19-OE or H19-KD and co-cultured with PBMCs for 24 h and 48 h. C and D The level of active IL-2 (C) and total IL-2 (D) in cultured supernatants of BMMSCs was detected by ELISA. E and F The role of H19 in the immunoregulatory function of BMMSCs on Treg cells (E) and migration (F) in medium supplemented with additional IL-2. *P < 0.05