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Fig. 2 | Molecular Medicine

Fig. 2

From: MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure

Fig. 2

MiR-125b overexpression alleviated cardiac function injury in HF mice. Mice were treated with or without TAC, then TAC mice were tail intravenously injected with agomir-125b or agomir-NC. A–C The mRNA levels of ANP (A), BNP (B) and β-MHC (C) were evaluated by qRT-PCR (n = 5). D Representative images of echocardiographic measurements of mouse hearts (n = 8). E Left ventricular ejection fraction (EF%) (n = 8). F Left ventricular fractional shortening (FS%) (n = 8). G Left ventricular septal thickness; diastole (IVS; d) (n = 8). H Left ventricular posterior wall thickness; diastole, (LVPW; d) (n = 8). I Left ventricular mass/body weight (LV mass/BW) (n = 8). J Representative images of H&E staining and Masson staining of mouse heart tissues (n = 8). K The statistical result of H&E staining (n = 5). L The statistical result of Masson staining (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. sham group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. TAC group

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