Fig. 5
From: MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure
BAK1 overexpression significantly reversed agomir-125b-induced protective effect in heart failure. TAC mice were transfected with agomor-125b, or co-transfected with agomir-125b and OE-BAK1, or agomir-125b and OE-NC. (A-C) The mRNA level of ANP (A), BNP (B) and β-MHC (C) was evaluated by qRT-PCR (n = 5). D Representative images of echocardiographic measurements of mice hearts (n = 8). E Left ventricular ejection fraction (EF%) (n = 8). F Left ventricular fractional shortening (FS%) (n = 8). G Left ventricular septal thickness; diastole (IVS; d) (n = 8). H Left ventricular posterior wall thickness; diastole, (LVPW; d) (n = 8). I Left ventricular mass/body weight (LV mass/BW) (n = 8). J Representative images of H&E staining and Masson staining of mouse heart tissues (n = 8). K The statistical result of H&E staining (n = 5). L The statistical result of Masson staining (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. TAC group; ## p < 0.01, ### p < 0.001 vs. TAC + agomir-125b group