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Fig. 6 | Molecular Medicine

Fig. 6

From: MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure

Fig. 6

BAK1 overexpression significantly reversed agomir-125b-inhibited cardiomyocyte apoptosis in HF mice. TAC mice were co-transfected with agomir-125b and OE-BAK1, or agomir-125b and OE-NC. A The protein expression of C-caspase 3, caspase 3, Bcl-2 and Bax in heart tissues was detected by western blot (n = 5). B–D The relative expression changes in C-caspase 3 (B), Bcl-2 (C) and Bax (D) were analyzed by Image Lab™ Software (n = 5). E Representative images of TUNEL staining of heart tissues by confocal microscopy (n = 8). F The apoptosis rate was calculated as the ratio of TUNEL positive nuclei to DAPI-stained nuclei (n = 5). * p < 0.05, ** p < 0.01, *** p < 0.001 vs. TAC group; # p < 0.05, ## p < 0.01, ### p < 0.001 vs. TAC + agomir-125b group

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