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Fig. 5 | Molecular Medicine

Fig. 5

From: CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis

Fig. 5

Effect of miR-182-5p overexpression or RASA1 knockdown on circMTO1-induced proliferation, apoptosis and migration of VSMCs. A Viability of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. B Proliferation of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. C Apoptosis of VSMC co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. D Migration of VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. * vs NC (OX-LDL) + capecitabine group, # vs circMTO1(OX-LDL) + capecitabine group. Ca. indicates the capecitabine. ** P < 0.01, #P < 0.05. E Western Blot results of capase3, cyclinD1, RASA1 and GADPH in VSMCs co-transfected with circMTO1 vector and miR-182-5p mimic or si-RASA1. * vs NC group, # vs circMTO1 group. *** P < 0.001, ** P < 0.01, #P < 0.05

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Molecular Medicine

ISSN: 1528-3658