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Fig. 6 | Molecular Medicine

Fig. 6

From: CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis

Fig. 6

CircMTO1 overexpression attenuated arteriosclerosis by sponging miR-182-5p in vivo. A Representative microscopic images of the aortic root of a 36-week-old ApoE−/− mice injected by AAV-modified vector via tail vein (AAV-PCDNA, AAV-pcDNA-circMTO1 and AAV-pcDNA-circMTO1/AAV-miR-182-5p). Lipid fixation was performed followed by oil red O (red) and smooth muscle α-actin (SMA, yellow) staining. B Western blot results of α-SMA, LDLR (LDL receptor), RASA1 and GADPH in the AS mice (AAV-PCDNA, AAV-pcDNA-circMTO1 and AAV-pcDNA-circMTO1/AAV-miR-182-5p). * vs NC group, # vs AS group, &vs AS + circMTO1, **P < 0.01, *P < 0.05, ##P < 0.01, #P < 0.05, &&P < 0.01, &P < 0.05

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