Table 3 Cox regression models of mutational load on survival
From: Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer
Variable | Univariate model | Multivariate model | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | |
Mutational load | ||||||
 0–3 variants | 1 (ref) |  |  | 1 (ref) |  |  |
 4–9 variants | 1.58 | 0.63–3.93 | 0.328 | 1.95 | 0.72–5.32 | 0.192 |
 10–22 variants | 3.51 | 1.45–8.52 | 0.006 | 3.64 | 1.37–9.67 | 0.009 |
Stage | ||||||
 I–IIIa |  |  |  | 1 (ref) |  |  |
 IIIb–IV |  |  |  | 1.898 | 0.70–5.11 | 0.205 |
ECOG PS | ||||||
 PS 0 |  |  |  | 1 (ref) |  |  |
 PS 1 |  |  |  | 1.19 | 0.39–3.70 | 0.76 |
 PS 2 |  |  |  | 3.30 | 1.06–10.31 | 0.04 |
 PS 3–4 |  |  |  | 76.05 | 14.95–386.85 | 0.000 |