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Fig. 7 | Molecular Medicine

Fig. 7

From: Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis

Fig. 7

Propofol alleviates I/R injury through the MALAT1/miR-144/GSK3β axis in vitro. A Expressions of MALAT1 and miR-144 in cells as detected by RT-qPCR (*p < 0.05, compared with the H/R + oe-NC + Propofol group). B Autophagy-related protein levels as detected by Western blotting (*p < 0.05, compared with the H/R + oe-NC + Propofol group; #p < 0.05, compared with H/R + Propofol + oe-MALAT1 + DMSO group). C Amount of autophagosome as determined by immunofluorescence against LC3 (*p < 0.05, compared with the H/R + oe-NC + Propofol group; #p < 0.05, compared with the H/R + Propofol + oe-MALAT1 + DMSO group). D Cell apoptosis as determined by flow cytometry (*p < 0.05, compared with the H/R + oe-NC + Propofol group; #p < 0.05, compared with the H/R + Propofol + oe-MALAT1 + DMSO group). E Levels of TNF-α, IL-1β, and IL-18 in supernatant of cells as measured by ELISA (*p < 0.05, compared with the H/R + oe-NC + Propofol group; #p < 0.05, compared with the H/R + Propofol + oe-MALAT1 + DMSO group). Cellular experiments are repeated 3 times independently

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