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Fig. 1 | Molecular Medicine

Fig. 1

From: The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion

Fig. 1

The expression and function of MEG3 in trophoblast of URSA. a Analysis of RNA expression profile using the GSE14722 data (RNA-seq data of embryonic villi from 11 abortion patients) and GSE9984 data (RNA-seq data of embryonic villi from 12 normal pregnant women). b The expression levels of MEG3 in embryonic villi from URSA patients and normal tissues using qRT-PCR assays. c Compare the expression of MEG3 in villi from URSA patients and PT-U cells (Primary trophoblast of URSA). d Compare the expression of MEG3 in PT-U cells and PT-N cells (normal primary trophoblast cells). e Compare the proliferative capacity of PT-U cells and PT-N cells. f The effect of MEG3 on the implantation capacity of mouse embryo in vitro. g The expression of MEG3 in MEG3 and shRNA-MEG3 transfected mouse embryo using qRT-PCR assays. h Effects of plasmids harboring MEG3 sequence and shRNA-MEG3 on the expression level of MEG3 in PT-U cells using qRT-PCR. i The effects of MEG3 on the proliferative capacity of PT-U cells using CCK-8 assay. **P < 0.01, *P < 0.05

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