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Fig. 4 | Molecular Medicine

Fig. 4

From: The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion

Fig. 4

EZH2 regulated RASA1 gene expression through histone methylation. a Bioinformatics analysis suggested presence of EZH2 protein binding site in RASA1 gene promoter. ChIP assay was used to detect the enrichment of EZH2 (b) and H3K27me3 (c) in RASA1 gene promoter of PT-U and PT-N cells. The enrichment of EZH2 in RASA1 gene promoter of pcDNA-EZH2 (d) and si-EZH2 (e) transfected PT-U cells. f The expression of RASA1 in pcDNA-EZH2 and si-EZH2 transfected PT-U cells was detected by qRT-PCR

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