Fig. 2

miR-182-5p stimulates proliferation, migration and angiogenesis of HUVECs. A miR-182-5p expression and MVD in metastasis tissues from 16 breast cancer patients with distant metastasis detected by ISH and immunohistochemical staining, the statistical power was 1; B Pearson correlation analysis of the relationship between miR-182-5p and MVD, the statistical power was 0.572; C miR-182-5p expression in HUVECs detected by RT-qPCR, the statistical power was 1; D VEGF protein expression in HUVECs detected by Western blot analysis, the statistical power was 1; E Proliferation of HUVECs detected by CCK-8 method, the statistical power was 1; F HUVECs migration ability detected by Scratch test, the statistical power was 1; G HUVECs migration ability detected by Transwell assay, the statistical power was 1; H Vessel-like tube formation in HUVECs, the statistical power was 1. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared with cells treated with mimic NC or breast cancer patients without distant metastasis; #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001 compared with cells treated with inhibitor NC. The experiment was conducted three times independently