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Fig. 4 | Molecular Medicine

Fig. 4

From: Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis

Fig. 4

EVs-miR-182-5p exerts promoting effects on HUVECs proliferation, migration and angiogenesis. HUVECs were treated with EVs + miR-182-5p inhibitor. A miR-182-5p expression of HUVECs detected by RT-qPCR, the statistical power was 1; B VEGF protein expression of HUVECs detected by Western blot analysis, the statistical power was 1; C The proliferation of HUVECs detected by CCK-8 assay, the statistical power was 1; D Migration ability of HUVECs detected by scratch test, the statistical power was 1; E Migration ability of HUVECs detected by Transwell assay, the statistical power was 1; F Vessel-like tube formation in vitro of HUVEC, the statistical power was 1. *p < 0.05, ***p < 0.001, ****p < 0.0001 compared with HUVEC; #p < 0.05, ##p < 0.01, ###p < 0.001 compared with HUVEC treated with EVs + inhibitor NC. The experiment was conducted three times independently

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Molecular Medicine

ISSN: 1528-3658