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Fig. 4 | Molecular Medicine

Fig. 4

From: ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Fig. 4

ets1 associated with KMT5A. A The enriched gene ontology (GO) terms. The vertical axis in the graph represents the number of significant proteins. The horizontal axes represent the enriched GO terms. (BP: biological processes; MF: molecular functions; CC: cellular components). B The association between ets1 and KMT5A in HUVECs was confirmed by co-IP. C Colocalization of ets1 and KMT5A in HUVECs was tested by confocal microscopy. D Results from the Western blot analysis of KMT5A and H4K20me1 in the HUVECs with the corresponding treatment. E Compared with the control group, the mRNA expression of KMT5A was decreased in hyperglycemic HUVECs. (* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, n = 5/group)

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