Table 1 Characteristics of participants and rats in control (con) and Diabetic Nephropathy (DN) group
Human | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects | Age (Year) | BMI (kg/m2) | SBP (mmHg) | DBP (mmHg) | HbA1C (%) | FBG (mmol/l) | CREA (umol/l) | ALB (g/L) | CCr (ml/min) | 24hUPQ (mg) | TPÂ (g/L) | eGFR (ml/min/) | |||
Normal control (n = 20) | |||||||||||||||
Male: 9/20 | 58.3 ± 7.3 | 23.4 ± 3.3 | 118.9 ± 15.2 | 69.2 ± 8.1 | 5.2 ± 0.8 | 5.2 ± 0.5 | 58.3 ± 10.5 | 47.2 ± 5.2 | 101.9 ± 10.8 | 95.5 ± 10.2 | 69.5 ± 7.3 | 130.1 ± 25.2 | |||
DN stage 2 (n = 7) | |||||||||||||||
Male: 3/7 | 57.4 ± 4.7 | 22.5 ± 2.3 | 133 ± 10.2 | 75.3 ± 8.3 | 6.8 ± 1.2 | 6.4 ± 0.8 | 100.2 ± 10.3 | 35.4 ± 3.2 | 80.9 ± 7.6 | 1499.4 ± 234.8 | 55.4 ± 6.1 | 71.4 ± 6.8 | |||
DN stage 3 (n = 7) | |||||||||||||||
Male: 4/7 | 60.2 ± 4.4 | 24.6 ± 2.5 | 142.8 ± 12.1 | 78.3 ± 8.2 | 7.2 ± 2.0 | 7.2 ± 2.3 | 155.9 ± 12.4 | 32.2 ± 2.9 | 65.5 ± 7.1 | 4233.4 ± 359.0 | 50.8 ± 5.0 | 48.5 ± 6.5 | |||
DN stage 4 (n = 6) | |||||||||||||||
Male: 3/6 | 59.1 ± 5.9 | 21 ± 4.3 | 147.3 ± 6.2 | 85.1 ± 6.9 | 8.9 ± 2.5 | 9.2 ± 3.1 | 265.8 ± 20.9 | 27.5 ± 3.6 | 39.8 ± 4.6 | 6750.4 ± 675.3 | 45.7 ± 8.0 | 23.4 ± 5.1 | |||
Rats | |||||||||||||||
Variables | Con | DM | P-value | ||||||||||||
CREA (umol/l) | 21.0 ± 2.2 | 39.7 ± 9.7 |  < 0.0001 | ||||||||||||
UREA (mmol/l) | 2.3 ± 0.2 | 6.4 ± 1.1 |  < 0.0001 | ||||||||||||
24hUTP (mg) | 31.7 ± 4.5 | 357.9 ± 70.3 |  < 0.0001 | ||||||||||||