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Fig. 2 | Molecular Medicine

Fig. 2

From: A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone

Fig. 2

Low miR-181a-5p expression suppresses the apoptosis and induces the proliferation of FD BMSCs. a Protein expression of Bcl-2 and Bax in BMSCs and FD BMSCs was detected by western blot. b Western blot analysis of Bcl-2 and Bax in FD BMSCs transfected with miR-181a-5p mimics. c Immunofluorescence analysis of Bcl-2 expression in FD BMSCs transfected with miR-181a-5p mimics. d Western blot analysis of Bcl-2 and Bax in BMSCs transfected with the miR-181a-5p inhibitor. e Immunofluorescence analysis of Bcl-2 expression in BMSCs transfected with the miR-181a-5p inhibitor. Representative BrdU incorporation in FD BMSCs transfected with miR-181a-5p mimics (f) and BMSCs transfected with the miR-181a-5p inhibitor (g). Scale bar, 100 μm. The data are presented as the mean ± S.E.M. values (n = 3). #P > 0.05; *P < 0.05; **P < 0.01

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