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Fig. 2 | Molecular Medicine

Fig. 2

From: The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

Fig. 2

NAC suppresses the expression of VWF. A The interaction network of NAC and genes. B Venn map of intersection of COPD target genes. C PPI network of intersection of COPD target genes. D Venn map of intersection of NAC and COPD target genes. E VWF expression in lung tissues of healthy individuals and COPD patients measured by immunohistochemistry (n = 10). F VWF expression in lung tissues of COPD rats measured by immunohistochemistry (n = 10). G VWF mRNA level in cells determined using RT-qPCR. H VWF protein level in cells determined using Western blot analysis. ***p < 0.001. ****p < 0.0001. Data are shown as the mean ± standard deviation of three technical replicates. Data between two groups were compared by independent sample t test. Data among multiple groups were compared by one-way ANOVA with Tukey’s post hoc test

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