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Fig. 6 | Molecular Medicine

Fig. 6

From: The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

Fig. 6

NAC affects the immune response in vivo through the VWF/p38 MAPK axis. COPD rats were treated with NAC and oe-VWF and/or sh-p38 MAPK (n = 10). A Expression of VWF and p38 MAPK, and the extent of p38 MAPK phosphorylation in lung tissues of COPD rats determined by Western blot analysis. B The ratio of CD3+, CD4+, CD8+ and CD4+/CD8+T lymphocytes in serum of COPD rats measured by flow cytometry. C Levels of IgG, IgA, and IgM in serum of COPD rats measured by ELISA. ****p < 0.0001. Data are shown as the mean ± standard deviation of three technical replicates. Data among multiple groups were compared by one-way ANOVA with Tukey’s post hoc test

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