Fig. 3
From: Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
Depleted SOX2 or PVT1 attenuates neurological deficits, motor behavioral and pathological damage in MCAO rats. A Neurological defect scores of rats in each group after inhibition of SOX2 or PVT1 (n = 8 rats per group); B Forelimb foot fault placing test scores of rats in each group after inhibition of SOX2 or PVT1 (n = 5 rats per group); C Parallel bar experiment scores of rats in each group after inhibition of SOX2 or PVT1 (n = 5 rats per group); D Rope climbing test scores of rats in each group after inhibition of SOX2 or PVT1 (n = 5 rats per group); E Brain water content of rats in each group after inhibition of SOX2 or PVT1 (n = 8 rats per group); F HE staining of rat brain injury in each group after inhibition of SOX2 or PVT1 (× 200; scale bar = 50 μm, n = 8 rats per group); arrow indicated that the nucleus of neurons appears with pyknosis; *P < 0.05 compared with the sham group; #P < 0.05 compared with the sh-NC group; &P < 0.05 compared with the sh-CTR group