Fig. 4
From: Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
Depleted SOX2 or PVT1 increases neuronal survival, reduces neuronal apoptosis and oxidative stress in the cerebral cortex of MCAO rats. A/B Nissl staining of neuron survival in each group after inhibition of SOX2 or PVT1 (× 200; scale bar = 50 μm, n = 8 rats per group); arrows indicated Nissl bodies; C/D TUNEL staining of neuronal apoptosis in each group after inhibition of SOX2 or PVT1 (× 200; scale bar = 50 μm, n = 8 rats per group); arrows indicated TUNEL-positive cells; E Oxidative stress indicators in the cortex of rats in each group after inhibition of SOX2 or PVT1 (n = 8 rats per group); *P < 0.05 compared with the sham group; #P < 0.05 compared with the sh-NC group; &P < 0.05 compared with the sh-CTR group