Fig. 6
From: Depleting SOX2 improves ischemic stroke via lncRNA PVT1/microRNA-24-3p/STAT3 axis
Restored miR-24-3p abolishes PVT1 overexpression-induced effects on neuronal survival, neuronal apoptosis and oxidative stress in the cerebral cortex of MCAO rats. A/B Nissl staining of neuron survival in each group after PVT1 overexpression and miR-24-3p up-regulation (× 200; scale bar = 50 μm, n = 8 rats per group); arrows indicated Nissl bodies; C/D TUNEL staining of neuronal apoptosis in each group after PVT1 overexpression and miR-24-3p up-regulation (× 200; scale bar = 50 μm, n = 8 rats per group; arrows indicated TUNEL-positive cells); E Oxidative stress indicators in the cortex of rats in each group after PVT1 overexpression and miR-24-3p up-regulation (n = 8 rats per group); ^P < 0.05 compared with the Lenti-NC group; $P < 0.05 compared with the Lenti-PVT1 group