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Fig. 3 | Molecular Medicine

Fig. 3

From: The long non-coding RNA DKFZp434J0226 regulates the alternative splicing process through phosphorylation of SF3B6 in PDAC

Fig. 3

Increased DKFZp434J0226 (DKFZ) expression is positively associated with poor prognosis of pancreatic ductal adenocarcinoma. A Coding-non-coding gene co-expression network analysis showing the association between DKFZ and genes involved in cancer growth (framed in red) and metastasis (framed in green). B RT-qPCR analysis showing the increased expression of DKFZ in PDAC compared to that in the corresponding non-tumor tissues (n = 109). C RT-qPCR analysis demonstrating the increased expression of DKFZ in six PDAC cell lines (AsPC-1, MIAPaCa-2, PANC-1, SW1990, CFPAC-1, and Capan-1) compared to that in immortal, transformed, human pancreatic ductal epithelial cells. D Typical patterns of DKFZ expression in paired PDAC tissues. Left panel: HE staining of paired PDAC tissue. Right panel: in situ hybridization of DKFZ in paired PDAC tissues. N, adjacent nontumorous tissues; T, tumor tissues. E Kaplan–Meier analysis for OS and TTR according to DKFZ expression (cutoff value: median value) in 109 patients with PDAC. Data are shown as mean ± SD; *P < 0.05, **P < 0.01

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