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Fig. 8 | Molecular Medicine

Fig. 8

From: The long non-coding RNA DKFZp434J0226 regulates the alternative splicing process through phosphorylation of SF3B6 in PDAC

Fig. 8

DKFZp434J0226 (DKFZ) inhibits xenograft tumor growth. MiaPaCa-2 cells infected with control lentivirus (control, n = 6) and DKFZ lentivirus (DKFZ, n = 7) were injected subcutaneously into nude mice. A Tumor size. B In vivo subcutaneous tumor growth curves. Data are shown as mean ± SD; *P < 0.05 vs. Mock and NC; **P < 0.01 vs. control. C Total tumor weight of each group of mice. D Western blotting analysis and quantification of SF3B6 phosphorylation levels in indicated tumors (n = 4). E The alternative spliced transcripts (MDM4-FL, MDM4 full-length transcript; MDM4-S, MDM4 S transcript) in the indicated tumors verified by RT-qPCR. The percent spliced in index was quantified for the alternative splicing events (n = 4). C–E Data are shown as mean ± SD; *P < 0.05, **P < 0.01

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