The long non-coding RNA DKFZp434J0226 regulates the alternative splicing process through phosphorylation of SF3B6 in PDAC

Table 1 Multivariate analyses of factors associated with OS and TTP

	Hazard ratio (95% CI)	P
OS
Tumor differentiation (I vs. II vs. III)	0.940 (0.488–1.811)	0.853
Tumor size (T1 vs. T2 vs. T3)	1.817 (0.668–4.944)	0.243
Lymph node metastasis (negative vs. positive)	1.263 (0.722–2.209)	0.414
Perineural invasion (negative vs. positive)	0.684 (0.336–1.392)	0.295
Vascular invasion (negative vs. positive)	1.336 (0.770–2.318)	0.002
TNM stage (I vs. II)	1.913 (0.470–7.795)	0.365
DKFZp434J0226 expression (low vs. high)	2.017 (1.154–3.527)	0.014
TTP
Age, years (≤ 60 vs. >60)	1.523 (0.877–2.647)	0.135
Tumor grade (I vs. II vs. III)	1.040 (0.566–1.912)	0.899
Tumor size (T1 vs. T2 vs. T3)	1.966 (0.812–4.764)	0.134
Lymph node metastasis (negative vs. positive)	1.481 (0.866–2.534)	0.151
Perineural invasion (negative vs. positive)	0.567 (0.289–1.111)	0.098
Vascular invasion (negative vs. positive)	1.385 (0.790–2.428)	0.006
TNM stage (I vs. II)	1.683 (0.474–5.970)	0.421
DKFZp434J0226 expression (low vs. high)	1.875 (1.085–3.237)	0.024

OS overall survival, TTP time to progression
Variables were adopted for prognostic significance using univariate analysis (P < 0.05). Bold P values less than 0.05, indicating statistical significance

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