Fig. 2
From: rAAV9‐mediated supplementation of miR-29b improve angiotensin-II induced renal fibrosis in mice
Decrease of miR-29b levels in mouse kidney during angiotensin II-induced renal fibrosis. Representative images of Masson trichrome staining (A) and a-SMA immune stain (B) of kidney with saline or angiotensin II infusion at different time points. Magnification, × 200. Right histogram represents quantitative analysis of tubular interstitial fibrosis. Results are presented as mean ± SEM. **P < 0.01 compared with control group. #P < 0.01 compared with angiotensin II infusion group (Day 14). Each group consisted of six mice. Scale bar 50 μm. C Real-time PCR further confirmed the decrease in miR-29b levels in renal tubular epithelium among different groups. Control, mice were treated with saline. AngII-14d, mice were treated with continuous angiotensin II infusion for 14 days. Ang II-28d, mice were treated with continuous angiotensin II infusion for 28 days. *P < 0.05 compared with control group. #P < 0.05 compared with angiotensin II infusion group (Day 14)