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Fig. 7 | Molecular Medicine

Fig. 7

From: CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

Fig. 7

CB2 Activation alleviates IVDD in vivo. SD rat coccygeal Co 7–8 vertebrae were punctured and treated with JWH133 and AM630. A Representative X-ray images of rats in the 4 groups (Control, Vehicle, JWH133, and AM630). B Quantitative analysis of DHI at different time points after the operation (*p < 0.05 compared with Vehicle group). C Representative MRI image of rats in the 4 groups. D Quantitative analysis of IVD optical density (*p < 0.05). E H&E and safranin O staining of the 4 experimental groups, scale bar, 1000 μm. F Representative IHC images of collagen II and MMP3 in the 4 experimental groups, scale bar, 1000 μm. G Quantitative statistics of the histological scores. H, I Quantitative analysis of the positive staining area for collagen II and MMP3 (p < 0.05). (n = 10 Independent experiments)

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Molecular Medicine

ISSN: 1528-3658