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Fig. 1 | Molecular Medicine

Fig. 1

From: Interleukin-22: a potential therapeutic target in atherosclerosis

Fig. 1

IL-22-mediated regulation and the major cardiometabolic risk factors of atherosclerosis. VCAM-1 vascular cell adhesion molecule-1, ICAM-1 Intercellular adhesion molecule-1, CXCLs CXC chemokine ligands, MAPK mitogen-activated protein kinase, STAT signal transducer and activator of transcription, VLDL very low-density lipoprotein, LDL low-density lipoprotein, HDL-C high-density lipoprotein cholesterol, ABCG1 ATP-binding cassette transporter G1, NF-κB nuclear transcription factor-κB, ERK extracellular signal-regulated kinase, VSMC vascular smooth muscle cell, TMAO trimethylamine N-oxide, LPS lipopolysaccharide, AS atherosclerosis. Arrows in red: promote; Arrows in green: inhibit; text in red: proatherogenic changes; text in green: antiatherogenic changes

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