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Fig. 3 | Molecular Medicine

Fig. 3

From: Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

Fig. 3

HucMSC-secreted exosomal miR-26a-5p targets METTL14 in HNPC. A Expression of miR-100-5p, miR-21-5p, miR-221-3p, miR-143-3p, and miR-27b-3p in HNPC with or without hucMSC coculture. B, C Pearson correlation scatter plots in D-HNP tissues (n = 20). D The predictive binding between miR-26a-5p and METTL14. E, G, H Relative expression of miR-26a-5p and METTL14 in D-HNPC transfected with miR-26a-5p mimic or its inhibitor. F Effect of miR-26a-5p mimic or its inhibitor on the luciferase activity of METTL14 3′-UTR wild type (WT) or mutant (Mut) in D-HNPC. **P < 0.01, ***P < 0.001

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