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Fig. 4 | Molecular Medicine

Fig. 4

From: Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

Fig. 4

The effects of hucMSC on METTL14 overexpression on HNPC are inhibited by miR-26a-5p inhibitor. A Cell viability, B LDH activity, C, D pyroptosis, E–G expression of METTL14, NLRP3, caspase-1, and GSDMD-N, and H content of IL-1β and IL-18 were measured in D-HNPC transduced with the METTL14 expression vector and treated with hucMSC-exo from hucMSC transfected with miR-26a-5p inhibitor (hucMSC/inhibitor-exo) or NC (hucMSC/NC-exo). ***P < 0.001

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