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Fig. 7 | Molecular Medicine

Fig. 7

From: Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

Fig. 7

The expression of NLRP3 correlates positively with METTL14 and IGF2BP2 and negatively with miR-26a-5p. A qRT-PCR analysis of METTL14, miR-26a-5p, NLRP3, and IGF2BP2 in N-HNP tissues (n = 10) and D-HNP tissues (n = 20). B Pearson correlation analysis among METTL14, miR-26a-5p, NLRP3, and IGF2BP2 level in 20 cases of D-HNP tissues. C Schematic representation of the regulation of HNPC inflammation and pyroptosis by hucMSC-secreted exosomal miR-26a-5p/METTL14/NLRP3/caspase-1. ***P < 0.001

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Molecular Medicine

ISSN: 1528-3658