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Fig. 1 | Molecular Medicine

Fig. 1

From: New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases

Fig. 1

COX and POX reactions are catalyzed by coxibs and quercetin-like natural plant compounds, respectively. COX-2 catalyzes arachidonic acid conversion to PGG2 by the COX activity site. The POX activity site of COX-2 reduces PGG2 to PGH2. Downstream prostaglandin products are formed from PGH2 via different synthases. The COX activity site of COX-2 but not the POXsite is inhibited by COX-2–selective inhibitors called coxibs. The labels of coxibs must carry a “black box” warning due to adverse cardiovascular events. Quercetin-like natural plant compounds decrease the risk of cardiovascular disease and serve as activators and cofactors of COX-2 to reduce the cardiotoxicity of coxibs by binding to the POX site

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Molecular Medicine

ISSN: 1528-3658