Table 1 Chemical structures of quercetin-like natural plant compounds as cofactors of COX-2

Lead compounds

Flavonoids

(Moore 2020; Bahmani et al. 2017; Mitchell, et al. 2020; Arora et al. 2020; Duarte et al. 2002)

Activator

Quercetin

(Moore 2020; Bahmani et al. 2017; Mitchell, et al. 2020; Arora et al. 2020)

Myricetin

(Moore 2020; Bahmani et al. 2017; Mitchell, et al. 2020; Arora et al. 2020)

Fisetin

(Moore 2020; Bahmani et al. 2017; Mitchell, et al. 2020; Arora et al. 2020)

Morin

(Moore 2020; Bahmani et al. 2017; Mitchell, et al. 2020; Arora et al. 2020)

5,4′-Dihydroxyflavone

(Moore 2020; Duarte et al. 2002)

7,4′-Dihydroxyflavone

(Moore 2020; Duarte et al. 2002)

Inhibitor

Galangin

(Chandel et al. 2018; Radi and Khan 2019; Seta et al. 2009)