Fig. 5
From: Reversible dysregulation of renal circadian rhythm in lupus nephritis
Partial correction of circadian dysfunction by remission induction therapy. A, B Bmal1 and Per2 protein expression measured in renal lysates by ELISA; C, D Bmal1 and Per2 expression measured in whole renal mRNA by qPCR; E, F Heatmap of 320 genes that differed between ZT0 (red bars) and ZT12 (Orange bars) in young but not nephritic kidneys showing correction of 205 genes (E) and failure to correct 115 genes (F). G Blood pressure in remission mice shows normalization of dipping pattern; H Correction of serum aldosterone in remission mice. *p < 0.05. Red symbols: young mice; Blue symbols: nephritic mice; Black symbols: remission mice—each symbol represents one mouse