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Fig. 4 | Molecular Medicine

Fig. 4

From: An mRNA assay system demonstrates proteasomal-specific degradation contributes to cardiomyopathic phospholamban null mutation

Fig. 4

RNA sequencing analysis from 32 h modPLN or modL39X post-transfected cardiomyocytes. A Immunostaining of re-plated Day 30 cardiomyocytes showing complementarity (Top) of α-Actinin (green) and cTnT (red) and co-localization signals (Bottom) of PLN (green) and SERCA (red). Scale bar = 50 µm B EdgeR normalized gene expression of selected cardiac genes. Bar graphs illustrate duplicate experiments of control, modPLN and modL39X transfected cardiomyocytes. C Representative Heatmap from selected gene subsets, 20S proteasome (top), unfolded protein response (middle) and autolysosome (bottom). D and E Bar graphs representing EdgeR normalized counts of selected 20S proteasome genes (D) and unfolded protein response genes (E). **P < 0.01

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